2026-10-05 · 原文发表于 2026-09-22
负载奥美沙坦的透明质酸修饰纳米水凝胶在大鼠糖尿病创面模型中的促愈作用
El-Dakroury WA, Asaad GF, Sallam AM, Elballal MS, ElRebehy MA, El-Tokhy FS, Elesawy AE, El Tabaa MM, El Tabaa MM, Abuhegara RM, Waly ASA, Zakaria AH, Elshabrawy AT, Sobhy R, Boles MR, Fathy AE, Said AR.. A repurposed olmesartan-loaded hyaluronic acid-functionalised lecithin-chitosan nanoparticle hydrogel for enhanced topical delivery in diabetic wound healing. Europe PMC · 创面修复文献. 2026.
查看原始文献（Europe PMC · 创面修复文献）↗研究问题
糖尿病创面常受持续氧化应激和组织重塑障碍影响而难以愈合。奥美沙坦被探索用于老药新用，但其局部应用需要合适的纳米载体来提升生物粘附性、缓释性能和生物相容性。
研究设计
主要发现
如何理解
局限与不确定性
一句话带走
该研究在大鼠模型中证实了负载奥美沙坦的纳米水凝胶具有良好的促愈与抗氧化潜能，但其临床可行性仍需深入的人体试验验证。
术语小注
- 奥美沙坦酯 (OLM)：
- 一种常用的血管紧张素II受体拮抗剂类降压药物，本研究探索其老药新用于局部创面抗氧化与修复。
- 卵磷脂-壳聚糖纳米颗粒 (LCNPs)：
- 由磷脂和壳聚糖复合物构建的纳米级药物递送载体，具有良好的生物相容性和缓释性能。
- 透明质酸 (HA)：
- 一种天然多糖，常用于纳米载体表面修饰以增强生物粘附性并辅助组织再生。
- 假塑性流变学：
- 指流体在受到剪切应力时粘度降低的流动特性，有助于外用制剂在创面顺畅涂抹与均匀铺展。
- 丙二醛 (MDA)：
- 生物体内脂质过氧化的最终产物，其水平常用于评估组织氧化应激损伤程度。
- 基质金属蛋白酶-9 (MMP-9)：
- 一种参与细胞外基质降解的蛋白酶，在难愈创面中过度表达常导致修复受阻。
展开原文摘要
A novel topical nanocarrier-based hydrogel system incorporating olmesartan medoxomil (OLM) was designed to enhance diabetic wound healing. OLM was efficiently encapsulated within lecithin-chitosan hybrid nanoparticles (LCNPs) and functionalized with hyaluronic acid (HA) to improve bioadhesion, biocompatibility, and sustained release. The optimized OLM-HA-LCNPs exhibited a nanoscale size of 324.28 ± 5.71 nm, a negative zeta potential (-39.64 ± 3.2 mV), and a high entrapment efficiency of 89.86 ± 3.15 %. In vitro release studies demonstrated a controlled, biphasic OLM release following Weibull kinetics, confirming diffusion erosion-controlled release behavior. Incorporation into a hydrogel base preserved pseudoplastic rheology, optimal pH (6.3 ± 0.2), and superior spreadability (35.26 cm 2 ). In streptozotocin-induced diabetic rats, the OLM-HA-LCNP hydrogel produced 93.5% wound closure after 14 days, compared with 87.6%, 77.1%, and 90.8% for the marketed reference, plain HA-LCNPs, and OLM-pure treatments, respectively. OLM-HA-LCNP hydrogel also increased CAT, SOD, and GSH levels by 2.7, 1.45, and 2.16 fold, respectively, and reduced MDA levels by 77% compared with diabetic controls. Histological and immunohistochemical findings further demonstrated improved epidermal regeneration, collagen deposition, and normalization of VEGF and MMP-9 expression. Collectively, these findings demonstrate that the OLM-HA-LCNPs hydrogel efficiently improves topical OLM delivery and therapeutic performance in diabetic wound healing.
本站中文摘要：该研究开发了负载奥美沙坦酯（OLM）的透明质酸（HA）功能化卵磷脂-壳聚糖纳米颗粒水凝胶，并通过体外材料与释药测试及链脲佐菌素诱导的糖尿病大鼠模型进行评价。优化后的纳米颗粒粒径为324.28±5.71 nm，包封率为89.86±3.15%，体外呈基于Weibull动力学的受控双相释药；水凝胶pH为6.3±0.2，铺展性为35.26 cm²。