2026-10-24 · 原文发表于 2026-09-29
富血小板血浆导电水凝胶：创面修复与温度监测的实验探索
Li Y, Liu Y, Guo Y, Li Y, Dong Y, Liu H, Meng Z, Zhao Z, Yu S, Liu Z, Liu J, Qin L, Ge D, Wang L, Jiang D, Wang H.. PRP-Integrated Conductive Hydrogels With Dynamic Crosslinking for Accelerated Wound Healing and Physiological Monitoring. Advanced healthcare materials. 2026;e71777. doi:10.1002/adhm.71777. PMID:42811379.
查看原始文献（Europe PMC · 创面修复文献）↗研究问题
摘要指出，关节等部位活动频繁且易发生感染，创面管理需要兼顾敷料的运动适应性、组织修复支持和实时监测。本研究围绕这些需求，尝试将生物活性成分与电子传感功能整合到同一种敷料中。
研究设计
主要发现
如何理解
局限与不确定性
一句话带走
作者报告了兼具修复相关生物活性、形变适应性和局部温度感知能力的水凝胶平台。现有摘要支持进一步研究其作为智能敷料的潜力，尚不能证明其人体疗效或感染诊断价值。
术语小注
- 富血小板血浆（PRP）：
- 富集血小板的血浆制品，本研究将其作为水凝胶中的生物活性成分。
- 导电水凝胶：
- 含有大量水分、能够传导电信号的聚合物网络，本研究利用其电阻变化感知温度。
- 动态交联：
- 网络中的部分连接可以断开并重新形成，有助于材料适应形变和实现自修复。
- MXene：
- 一类二维材料；本研究使用Ti₃C₂Tₓ MXene作为水凝胶的组成成分，参与导电和网络连接。
- 胶原重塑：
- 修复过程中胶原不断更新和重新排列的过程；这一指标本身不等同于组织功能已完全恢复。
展开原文摘要
The capability to simultaneously promote wound healing and enable real-time monitoring is critical for effective wound management, especially in dynamic and infection-prone regions such as joints, yet unmet needs remain in clinical practice. Herein, we present a multifunctional hydrogel dressing composed of gold nanoparticles (AuNPs), Ti 3 C 2 T x MXene, poly(acrylamide), and platelet-rich plasma (PRP), designed to both accelerate tissue regeneration and provide continuous physiological monitoring. The integration of surface-functionalized MXene and AuNPs introduces both dynamic and covalent bonding connections (hydrogen, covalent, and Au─S bonds), endowing the hydrogel with remarkable stretchability (∼1000%), rapid self-healing, and robust wet tissue adhesion to accommodate skin deformation during motion. PRP further enhances angiogenesis, collagen remodeling, and cell proliferation, significantly improving in vivo healing outcomes. Crucially, the hydrogel's conductive and thermo-responsive matrix enables resistance-based sensing of local temperature changes, offering continuous, noninvasive feedback on wound status. This dual-functional platform unites regenerative bioactivity with electronic responsiveness, addressing urgent clinical needs for adaptive healing and intelligent diagnostics, which is thus providing a promising strategy for next-generation smart dressings in wearable and personalized medicine.
本站中文摘要：该研究构建了由金纳米颗粒、Ti₃C₂Tₓ MXene、聚丙烯酰胺和富血小板血浆（PRP）组成的多功能水凝胶敷料，用于创面修复及局部温度连续监测。材料通过氢键、共价键和Au─S键形成动态与共价连接，具有约1000%的伸缩性、快速自愈性和湿组织黏附性；PRP被用于促进血管新生、胶原重塑和细胞增殖，正文报告其改善了体内创面愈合结果。