2026-10-28 · 原文发表于 2026-09-22
壳聚糖基自黏附水凝胶在糖尿病创面愈合中的治疗潜力
Correia C, Sousa RO, Ibrahim NA, Fadilah NIM, Maarof M, Silva TH, Reis RL, Pashkuleva I, Alves NM, Fauzi MB.. Therapeutic potential of chitosan-based bioadhesive hydrogels in diabetic wound healing. International journal of biological macromolecules. 2026;154569. doi:10.1016/j.ijbiomac.2026.154569. PMID:42772480.
查看原始文献（Europe PMC · 创面修复文献）↗研究问题
糖尿病创面愈合困难，常导致慢性溃疡。已有研究提示具有抗菌和促进血管生成能力的材料可能有助于改善愈合。本研究关注一种新型水凝胶材料在糖尿病创面模型中的应用。
研究设计
主要发现
如何理解
局限与不确定性
一句话带走
Chit-Cat水凝胶在糖尿病创面模型中显示出改善愈合的潜力，但尚需更多临床研究验证其在人体中的疗效和安全性。
术语小注
- 自黏附：
- 材料能够与组织表面结合，减少移位或脱落，有助于维持治疗位置。
- 自修复：
- 材料在受到损伤后能够自动恢复其结构完整性，提升使用稳定性。
- 血管生成：
- 新血管形成的过程，对创面愈合至关重要。
- 巨噬细胞：
- 免疫细胞，参与炎症反应和组织修复，分为促炎和抗炎两种类型。
- 胶原纤维：
- 创面愈合过程中形成的结缔组织成分，其结构和分布影响愈合质量。
- 儿茶酚功能化：
- 通过引入儿茶酚基团增强材料的黏附性、抗菌性和生物活性。
展开原文摘要
We describe adhesive and self-healing hydrogels of chitosan functionalized with catechol groups (Chit-Cat) and crosslinked with β-glycerophosphate for the treatment of chronic diabetic wounds. Catechol functionalization enhanced the antibacterial activity of the hydrogels, eliminating both Gram-negative and Gram-positive bacteria while preserving excellent cytocompatibility against human dermal fibroblasts from aged diabetic donors. The efficacy of this therapeutical approach was assessed in vivo in a mice diabetic wound model. The results demonstrated that the treatment with Chit-Cat hydrogels decreased the wound area with no contraction compared to the treatment controls. Additionally, these hydrogels significantly enhanced angiogenesis in the treated wounds, decreased the pro-inflammatory macrophages, and facilitated a controlled transition from the inflammatory to the proliferative phase, characterized by an early prevalence of thick collagen fibers. These data suggest that Chit-Cat hydrogels offer a promising solution for wound dressing and the management of diabetic skin wounds, providing a multifunctional platform that accelerates and improves the healing in challenging clinical scenarios.
本站中文摘要：该研究开发了以儿茶酚功能化壳聚糖（Chit-Cat）和β-甘油磷酸交联形成的黏附、自修复水凝胶，并在体外及糖尿病小鼠创面模型中评估其表现。儿茶酚功能化增强了水凝胶对革兰阴性和革兰阳性细菌的抗菌活性，同时对来自老年糖尿病供体的人真皮成纤维细胞保持良好细胞相容性。