2026-10-30 · 原文发表于 2026-09-19
花状 Ag₂CO₃ 与 Ag/Ag₂CO₃ 纳米结构在糖尿病小鼠中显示良好的生物相容性与多重功效
Umar A, Roy D, Khan MU, Imanov H, Rahmat SA, Nazeer N, Ruzieva M, Umirkulova F, Avazmetova I, Singh S.. Biocompatibility and Multifunctional Biological Evaluation of Flower-Shaped Ag₂CO₃ and Ag/Ag₂CO₃ Nanostructures in Diabetic Albino Mice. Applied biochemistry and biotechnology. 2026. doi:10.1007/s12010-026-05910-8. PMID:42760450.
查看原始文献（Europe PMC · 创面修复文献）↗研究问题
糖尿病常伴随慢性伤口愈合障碍、氧化应激增加和感染风险升高。纳米材料因其独特的物理化学特性，在糖尿病管理中展现出潜力。此前研究提示金属纳米结构可能具有抗氧化、促愈合和抗菌作用，但其在糖尿病动物模型中的综合性能仍需系统评估。
研究设计
主要发现
如何理解
局限与不确定性
一句话带走
花状 Ag₂CO₃ 与 Ag/Ag₂CO₃ 纳米结构在糖尿病小鼠模型中显示良好的生物相容性和多重生物学活性，尤其 Ag/Ag₂CO₃ 表现更优。但尚需进一步研究以确认其在人类中的安全性和有效性。
术语小注
- 纳米结构：
- 具有纳米尺度（通常为1-100纳米）的材料结构，因其独特的物理化学特性，在生物医学领域具有广泛应用潜力。
- 抗氧化活性：
- 机体清除自由基或抑制氧化应激的能力，有助于减少细胞损伤，常用于评估物质对慢性疾病如糖尿病的保护作用。
- 伤口愈合：
- 组织修复过程，包括炎症、增生和重塑阶段，是评估材料或治疗对慢性伤口管理效果的重要指标。
- 生物相容性：
- 材料与生物体相互作用时，不引起明显不良反应的能力，是评估材料是否适用于生物医学应用的关键指标。
- Zeta电位：
- 描述颗粒在液体中表面电荷的物理参数，用于评估纳米颗粒的胶体稳定性，数值越绝对值越大，稳定性越高。
- 糖尿病小鼠模型：
- 通过化学或遗传方法诱导小鼠出现高血糖和糖尿病症状的动物模型，用于评估糖尿病相关治疗效果。
展开原文摘要
The present study aimed to synthesize Ag₂CO₃ and Ag/Ag₂CO₃ nanostructures and to systematically investigate their physicochemical characteristics, biocompatibility, metabolic effects, wound healing potential, antioxidant activity, and antibacterial efficacy. Both nanostructures were synthesized using a controlled chemical reduction method. X-ray diffraction analysis confirmed the crystalline Ag₂CO₃ phase and the successful incorporation of metallic silver in the Ag/Ag₂CO₃ composite, while zeta potential analysis revealed enhanced colloidal stability for Ag/Ag₂CO₃ (approximately - 38 mV) compared with Ag₂CO₃ (approximately - 28 mV). Biocompatibility and safety evaluation in non-diabetic mice, including complete blood count, liver and renal function tests, and lipid profiling, demonstrated that both nanostructures were well tolerated at the administered doses without evidence of severe toxicity. In alloxan-induced diabetic mice, treatment with Ag₂CO₃ and Ag/Ag₂CO₃ resulted in significant glucose-lowering effects from Day 7 onward. Serum insulin, triiodothyronine (T3), and thyroxine (T4) levels were significantly improved at Days 14 and 28 compared with diabetic controls. Antioxidant assessment after 28 days showed reduced malondialdehyde levels and enhanced activities of superoxide dismutase, catalase, and reduced glutathione. In a diabetic excision wound model with an initial wound area of 1.2 cm 2 , complete wound healing occurred by Day 19 in diabetic controls, Day 17 in Ag₂CO₃-treated mice, and Day 14 in Ag/Ag₂CO₃-treated mice. Additionally, both nanostructures exhibited concentration-dependent antibacterial activity against Staphylococcus aureus and Escherichia coli, with Ag/Ag₂CO₃ producing inhibition zones of up to approximately 17 mm at 100 µg/mL. Overall, Ag/Ag₂CO₃ nanostructures demonstrated superior multifunctional biomedical performance.
本站中文摘要：该前临床研究在糖尿病小鼠切除创模型及非糖尿病小鼠安全性评价中，比较了 Ag₂CO₃ 和 Ag/Ag₂CO₃ 纳米结构的理化性质、生物相容性、代谢效应、创面愈合、抗氧化和抗菌活性。