创面愈合、成纤维细胞异质性与纤维化：研究进展综述
原题：Wound healing, fibroblast heterogeneity, and fibrosis.
参考文献：Talbott HE, Mascharak S, Griffin M, Wan DC, Longaker MT.. Wound healing, fibroblast heterogeneity, and fibrosis. Cell stem cell. 2022;29(8):1161-1180. doi:10.1016/j.stem.2022.07.006. PMID:35931028.
摘要
这篇综述以皮肤创面修复为重点，梳理成纤维细胞生物学及其异质性，以及其在组织修复和纤维化中的作用。文章讨论成纤维细胞参与生理性与病理性细胞外基质沉积、重塑的机制，并介绍新兴研究技术及现有方法与知识的局限。作者指出，相关机制仍处于逐步认识阶段；所给摘要未报告系统检索方法或定量证据合成结果。
展开来源摘要
Fibroblasts are highly dynamic cells that play a central role in tissue repair and fibrosis. However, the mechanisms by which they contribute to both physiologic and pathologic states of extracellular matrix deposition and remodeling are just starting to be understood. In this review article, we discuss the current state of knowledge in fibroblast biology and heterogeneity, with a primary focus on the role of fibroblasts in skin wound repair. We also consider emerging techniques in the field, which enable an increasingly nuanced and contextualized understanding of these complex systems, and evaluate limitations of existing methodologies and knowledge. Collectively, this review spotlights a diverse body of research examining an often-overlooked cell type-the fibroblast-and its critical functions in wound repair and beyond.